Glossary of NINDS terms on Dementia

NINDS, the National Institute of Neurological Disorders and Stroke has put together the following glossary of terms that caregivers should familiarize themselves with:

Alpha-synuclein—a protein that is implicated in abnormal clumps called Lewy bodies, which are seen in the brains of people with Parkinson’s disease and some dementias. Disorders in which alpha-synuclein accumulates inside nerve cells are called synucleinopathies.

Alzheimer’s disease—the most common cause of dementia in people age 65 and older. Nearly all brain functions, including memory, movement, language, judgment, and behavior, are eventually affected.

Amyloid—a protein found in the characteristic clumps of tissue (called plaques) that appear in the brains of people with Alzheimer’s disease.

Chronic traumatic encephalopathy—a form of dementia caused by repeated traumatic brain injury.

Corticobasal degeneration—a progressive disorder characterized by nerve cell loss and atrophy in multiple areas of the brain.

Dementia—a term for a collection of symptoms that significantly impair thinking and normal activities and relationships.

Dementia with Lewy bodies—a type of Lewy body dementia that is a common form of progressive dementia.

Frontotemporal disorders—a group of dementias characterized by degeneration of nerve cells, especially those in the frontal and temporal lobes of the brain.

HIV-associated dementia—a dementia that results from infection with the human immunodeficiency virus that causes AIDS.

Lewy body dementia—one of the most common types of progressive dementia, characterized by the presence of abnormal structures called Lewy bodies in the brain.

Mixed dementia—dementia in which one form of dementia and another condition or dementia cause damage to the brain, for example, Alzheimer’s disease and small vessel disease or vascular dementia.

Multi-infarct dementia—a type of vascular dementia caused by numerous small strokes in the brain.

Neurofibrillary tangles—bundles of twisted filaments found in nerve cells in the brains of people with Alzheimer’s disease. These tangles are largely made up of a protein called tau.

Parkinson’s disease dementia—a secondary dementia that sometimes occurs in people with advanced Parkinson’s disease. Many people with Parkinson’s have the amyloid plaques and neurofibrillary tangles found in Alzheimer’s disease, but it is not clear if the diseases are linked.

Tau—a protein that helps the functioning of microtubules, which are part of the cell’s structural support and help deliver substances throughout the cell. In Alzheimer’s disease, tau twists into filaments that become tangles. Disorders associated with an accumulation of tau, such as frontotemporal dementia, are called tauopathies.

Vascular dementia—a type of dementia caused by brain damage from cerebrovascular or cardiovascular problems, usually strokes.

By learning all you can as an elderly caregiver, you are displaying the most important thing and that is With Age Comes Respect!


About melissalstoneburner

Melissa is the proud mother of two boys. She also like to take care of all of her elderly clients as though they were her actual flesh and blood, too. Melissa began her elderly care business, Time to Care, in August, 2012. Since then, she has successfully seen several clients through life and onto the next life. She writes about what she knows, what she doesn't know, and reveals all the research in between. She believes that elderly care is the best thing she has ever done in life; second only to being a mother!
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